000			02078cmm a2200265 a 4500
001			46699
003			IN-BdCUP
005			20230426175552.0
008			230426s2023 u eng
020			_a9781439839744
040			_beng _cIN-BdCUP
041			_aeng
082			_a615.704 _bM592
245		0	_aMethods for studying nucleic acid/drug interactions / _c[edited by] Meni Wanunu, Yitzhak Tor
260			_aBoca Raton : _bCRC Press, _c2012
300			_a1 online resource (xviii, 373 pages)
505			_asection 1. Classical techniques -- section 2. Emerging techniques
520			_aSince most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the efficacy and nature of interactions between nucleic acids and their putative ligands. This progress can benefit tremendously from new methods that probe nucleic acid/ligand interactions both rapidly and quantitatively. A variety of novel methods for these studies have emerged in recent years, and Methods for Studying DNA/Drug Interactions highlights new and non-conventional methods for exploring nucleic acid/ligand interactions. Designed to present drug-developing companies with a survey of possible future techniques, the book compares their drawbacks and advantages with respect to commonly used tools. Perhaps more importantly, this book was written to inspire young scientists to continue to advance these methods into fruition, especially in light of current capabilities for assay miniaturization and enhanced sensitivity using microfluidics and nanomaterials--Provided by publisher
650			_aNucleic Acids
650			_aDrug interactions
700			_aWanunu, Meni _eEditor
700			_aTor, Yitzhak
856			_3Electronic Book Resource _uhttps://www.taylorfrancis.com/books/9781439839744
942			_2ddc _cE
999			_c48709 _d48709