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Human molecular genetics / T. Strachan and Andrew P. Read

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Boca Raton : CRC Press, Taylor & Francis Group, 2019.Description: xiii, 770 p. ; 27 cm. PBISBN:
  • 9780815345893
Subject(s): DDC classification:
  • 616.042 STR
Contents:
pt. 1: Basics of DNA, chromosomes, cells, development and inheritance Basic principles of nucleic acid structure and gene expression Fundamentals of cells and chromosomes Fundamentals of cell-cell interactions and immune system biology Aspects of early mammalian development, cell differentiation, and stem cells Patterns of inheritance pt. 2: Understanding genomes Core DNA technologies: amplifying DNA, nucleic acid hybridization, and DNA sequencing Analyzing the structure and expression of genes and genomes Principles of genetic manipulation of mammalian cells Uncovering the architecture and workings of the human genome Gene regulation and the epigenome pt. 3: Genetic variation between individuals and species An overview of human genetic variation Human population genetics Comparative genomics and genome evolution Human evolution pt. 4: Human genetic disease Chromosomal abnormalities and structural variants Moleculars pathology: connecting phenotypes to genotypes Mapping and identifying genes for monogenic disorders Complex disease identifying susceptibility factors and understanding pathogenesis Cancer genetics and genomics pt. 5: Applied human molecular genetics Genetic testing in healthcare and the law Model organisms and modeling disease Genetic approaches to treating disease
Summary: :Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology. Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation. Table of Contents Part 1: Basics of DNA, Chromosomes, Cells, Development, and Inheritance 1. Basic Principles of Nucleic Acid Structure and Gene Expression. 2. Fundamentals of Cells and Chromosomes. 3. Fundamentals of Cell-Cell Interactions and Immune System Biology. 4. Aspects of Early Mammalian Development, Cell Differentiation, and Stem Cells. 5. Patterns of Inheritance. Part 2: Understanding Genomes 6. Core DNA Technologies: Amplifying DNA, Nucleic Acid Hybirdization, and DNA Sequencing. 7. Analyzing the Structure and Expression of Genes and Genomes. 8. Principles of Genetic Manipulation of Mammalian Cells. 9. Uncovering the Architecture and Workings of the Human Genome. 10. Gene Regulation and the Epigenome. Part 3: Genetic Variation Between Individuals and Species 11. An Overview of Human Genetic Variation. 12. Human Population Genetics. 13. Comparative Genomics and Genome Evolution. 14. Human Evolution. Part 4: Human Genetic Disease 15. Chromosomal Abnormalities and Structural Variants. 16. Molecular Pathology: Connecting Phenotypes to Genotypes. 17. Mapping and Identifying Genes for Monogenic Disorders. 18. Complex Disease: Identifying Susceptibility Factors and Understanding Pathogenesis. 19. Cancer Genetics and Genomics. Part 5: Applied Human Molecular Genetics 20. Genetic Testing in Healthcare and the Law. 21. Model Organisms and Modeling Disease. 22. Genetic Approaches to Treating Disease
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Book Book Ranganathan Library Human Genetics and Molecular Medicine 616.042 STR (Browse shelf(Opens below)) Available 048032

pt. 1: Basics of DNA, chromosomes, cells, development and inheritance
Basic principles of nucleic acid structure and gene expression
Fundamentals of cells and chromosomes
Fundamentals of cell-cell interactions and immune system biology
Aspects of early mammalian development, cell differentiation, and stem cells
Patterns of inheritance
pt. 2: Understanding genomes
Core DNA technologies: amplifying DNA, nucleic acid hybridization, and DNA sequencing
Analyzing the structure and expression of genes and genomes
Principles of genetic manipulation of mammalian cells
Uncovering the architecture and workings of the human genome
Gene regulation and the epigenome
pt. 3: Genetic variation between individuals and species
An overview of human genetic variation
Human population genetics
Comparative genomics and genome evolution
Human evolution
pt. 4: Human genetic disease
Chromosomal abnormalities and structural variants
Moleculars pathology: connecting phenotypes to genotypes
Mapping and identifying genes for monogenic disorders
Complex disease identifying susceptibility factors and understanding pathogenesis
Cancer genetics and genomics
pt. 5: Applied human molecular genetics
Genetic testing in healthcare and the law
Model organisms and modeling disease
Genetic approaches to treating disease

:Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology. Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation. Table of Contents Part 1: Basics of DNA, Chromosomes, Cells, Development, and Inheritance 1. Basic Principles of Nucleic Acid Structure and Gene Expression. 2. Fundamentals of Cells and Chromosomes. 3. Fundamentals of Cell-Cell Interactions and Immune System Biology. 4. Aspects of Early Mammalian Development, Cell Differentiation, and Stem Cells. 5. Patterns of Inheritance. Part 2: Understanding Genomes 6. Core DNA Technologies: Amplifying DNA, Nucleic Acid Hybirdization, and DNA Sequencing. 7. Analyzing the Structure and Expression of Genes and Genomes. 8. Principles of Genetic Manipulation of Mammalian Cells. 9. Uncovering the Architecture and Workings of the Human Genome. 10. Gene Regulation and the Epigenome. Part 3: Genetic Variation Between Individuals and Species 11. An Overview of Human Genetic Variation. 12. Human Population Genetics. 13. Comparative Genomics and Genome Evolution. 14. Human Evolution. Part 4: Human Genetic Disease 15. Chromosomal Abnormalities and Structural Variants. 16. Molecular Pathology: Connecting Phenotypes to Genotypes. 17. Mapping and Identifying Genes for Monogenic Disorders. 18. Complex Disease: Identifying Susceptibility Factors and Understanding Pathogenesis. 19. Cancer Genetics and Genomics. Part 5: Applied Human Molecular Genetics 20. Genetic Testing in Healthcare and the Law. 21. Model Organisms and Modeling Disease. 22. Genetic Approaches to Treating Disease

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